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Medical Literature

Here is a selection of links and research articles on ketamine and lidocaine for depression, PTSD, pain, and other conditions. The articles here represent a portion of the information available, and are meant to supplement your own research and discussions with your referring physician.

Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression

Marije aan het Rot, Katherine A. Collins, James W. Murrough, Andrew M. Perez, David L. Reich, Dennis S. Charney, Sanjay J. Mathew

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

Anita E. Autry, Megumi Adachi, Elena Nosyreva, Elisa S. Na,Maarten F. Los, Peng-fei Cheng, Ege T. Kavalali, Lisa M. Monteggia

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

Nancy Diazgranados, Lobna Ibrahim, Nancy E. Brutsche, Andrew Newberg, Phillip Kronstein, Sami Khalife, William A. Kammerer,et al

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

Ronald S. Duman, George K. Aghajanian

Signaling Pathways Underlying the Rapid Antidepressant Actions of Ketamine

Ronald S. Duman, Nanxin Li, Rong-Jian Liu, Vanja Duric, George K. Aghajanian

Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder: A Randomized Clinical Trial

Adriana Feder, Michael K. Parides, James W. Murrough, Andrew M. Perez, Julia E. Morgan, Shireen Saxena, Katherine Kirkwood, et al

Multi-Day Low Dose Ketamine Infusion for the Treatment of Complex Regional Pain Syndrome

Michael E. Goldberg, Richard Domsky, Denise Scaringe, Robert Hirsh, Jessie Dotson, Imran Sharaf, Marc C. Torjman, Robert J. Schwartzman

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

Nanxin Li, Rong-Jian Liu, Jason M. Dwyer, Xiao-Yuan Li, George Aghajanian, Ronald S. Duman, et al

Maintenance Ketamine Treatment Produces Long-term Recovery from Depression

Michael M. Messer, Irina V. Haller

Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial

James W. Murrough, Dan V. Iosifescu, Lee C. Chang, Rayan K. Al Jurdi, Charles E. Green, Andrew M. Perez, et al

Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression

James W. Murrough, Andrew M. Perez, Sarah Pillemer, Jessica Stern, Michael K. Parides, Marije aan het Rot., et al

Efficacy and adverse effects of intravenous lignocaine therapy in fibromyalgia syndrome

Raphael JH, Southall JL, Treharne GJ, Kitas GD

Intravenous Therapies in the Management of Neuropathic Pain: A Review on the Use of Ketamine and Lidocaine in Chronic Pain Management

Harsha Shanthanna

Differential Efficacy of Ketamine in the Acute versus Chronic Stages of Complex Regional Pain Syndrome in Mice

Maral Tajerian, David Leu, Phillip Yang, Ting Ting Huang, Wade S. Kingery, J. David Clark

A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression

Carlos A. Zarate, Jaskaran B. Singh, Paul J. Carlson, Nancy E. Brutsche, Rezvan Ameli, et al

The Impact of Childhood Maltreatment on Intravenous Ketamine Outcomes in Adult Patients with Treatment Resistant Depression

Brittany O’Brien, Marijn Lijffijt, Allison Wells, Alan C Swann, Sanjay J Mathew
Articles

STUDIES

Explore a curated selection of research studies and clinical articles on ketamine and lidocaine for depression, PTSD, pain, and related conditions. These resources reflect the growing body of evidence supporting infusion therapy and are intended to complement discussions with your healthcare provider.

The Effect of Ketamine Infusion Treatment Schedule on Depression Severity

Brittany O’Brien, Allison Wells, Marijin Lijffijt, Michelle Davis, Jesse Wells, Alan C. Swann, Sanjay J. Mathew

Does Childhood Trauma Impact Outcomes in Adults Receiving Ketamine for Depression?

Brittany O’Brien, Allison Wells, Marijin Lijffijt, Michelle Davis, Jesse Wells, Alan C. Swann, Sanjay J. Mathew

The Impact of Childhood Maltreatment on Intravenous Ketamine Outcomes for Adult Patients with Treatment-Resistant Depression

Brittany O’Brien, Marijin Lijffijt, Allison Wells, Alan C. Swann, Sanjay J. Mathew

Important Notice Regarding Discontinuation of Ketamine Treatment Services

Lone Star Infusion will discontinue providing ketamine infusion and treatment services effective February 23, 2026. This decision was not made lightly, and we understand this news may be concerning to you.

What This Means for Your Care

After February 23, 2026 our clinic will no longer provide ketamine treatments. You will need to establish care with another provider to continue ketamine therapy, or work with your treating psychiatrist or pain management physician to explore alternative treatment options.

Your Immediate Next Steps

  1. Contact your prescribing psychiatrist, primary care physician, or pain management specialist to discuss your ongoing treatment plan and alternatives.
  2. If you wish to continue ketamine therapy, please review the enclosed list of physician-supervised ketamine clinics in the Houston area. We do not endorse any particular provider; this list is provided for your convenience only.
  3. Contact our office to schedule any final appointments before [closure date] and to discuss your transition of care.

Your Medical Records

Your treatment records will remain available through Lone Star Infusion. To request copies of your records or to authorize transfer to a new provider, please contact our office at 281.947.3268 or send a written request to 14740 Barryknoll Lane, Ste. 140, Houston, TX 77079. There is no charge for transferring records to your new treatment provider.

Continuation of Care During Transition

We stay committed to your care during this transition period. Please contact our office at 281.947.3268 if you have questions, need to schedule appointments before our closure date, or require assistance with your transition to a new provider.

We understand this transition may be difficult, and we appreciate the trust you have placed in us for your care. Our staff is available to assist you during this process.

Sincerely,
Chauncey Jones, M.D.
Lone Star Infusion