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What Is a Brain SPECT Scan? How It Helps Diagnose Complex Mental Health Conditions

Brain Scan Image

SPECT stands for Single-Photon Emission Computed Tomography. It is a type of nuclear medicine imaging test that can be used to evaluate many different parts of the body, including the brain. Nuclear imaging tests use tracers to show differences in activity in various parts of the body or a particular organ. Other nuclear tests include Bone Scans, PET Scans, Nuclear Heart Stress Tests. 

A Brain SPECT scan can be used to help determine parts of the brain that are either working appropriately, underworking, or overworking. Brain work activity is based on the amount of tracer uptake in certain parts of the brain during rest and during stress or concentration. The information from the SPECT scan combined with clinical history can help to diagnose or confirm specific brain disorders. These could include traumatic brain disorders (TBI), stroke, dementia, long covid, and various mental health disorders to include anxiety, depressionOCD, ADD/ADHD, and others.

Many mental health cases can be diagnosed by history and physical examination and respond appropriately to typical treatments and therapies. However, more complex cases may be difficult to diagnose, may be misdiagnosed, and may not respond to usual therapies. These treatment resistant cases can be better assessed with additional data from a Brain SPECT Scan.

At Lone Star Infusion Ketamine clinic, we take a multidisciplinary approach to your care. Some patients come to LSI with a team already in place that may include a psychiatrist, therapist, life coach, and others. Many patients request help from Lone Star Infusion because their condition has been difficult to diagnose and/or treatment resistant. In some cases, a Brain SPECT Scan may help to better focus our multidisciplinary approach and therapy.

Call or email Lone Star Infusion to discuss you case, determine if SPECT Scan is right for you.

Frequently Asked Questions about SPECT Scans

1. What is SPECT Scan?

SPECT stands for Single-Photon Emission Computed Tomography. It is a type of nuclear medicine imaging test that can be used to evaluate many different parts of the body, including the brain. Nuclear imaging tests use tracers to show differences in activity in various parts of the body or a particular organ. Other nuclear tests include Bone Scans, PET Scans, Nuclear Heart Stress Tests.

2. What is the purpose of a Brain SPECT Scan? Is it for diagnostic purposes only, or can it actually “help” me?

A Brain SPECT scan can be used to help determine parts of the brain that are either working appropriately, underworking, or overworking. Brain work activity is based on the amount of tracer uptake in certain parts of the brain during rest and during stress or concentration. The information from the SPECT scan combined with clinical history can help to diagnose or confirm specific brain disorders. These could include traumatic brain disorders (TBI), stroke, dementia, long covid, and various mental health disorders to include anxiety, depression, OCD, ADD/ADHD, and others.

3. Is a Brain SPECT Scan needed to diagnose mental health conditions?

Many mental health cases can be diagnosed by history and physical examination and respond appropriately to typical treatments and therapies. However, more complex cases may be difficult to diagnose, may be misdiagnosed, and may not respond to usual therapies. These treatment resistant cases can be better assessed with additional data from a Brain SPECT Scan.

4. Is Brain SPECT Scan covered by Insurance?

Insurance plans vary greatly in what they cover and under what conditions they will cover. There can be variability even with different plans within the same insurance company. While Brain SPECT Scans may be covered for “organic” concerns, such as brain cancer; SPECT is often not covered for Mental Health conditions, such as ADHD, anxiety, and depression.

As with all of our ketamine infusion patients, we can provide a summary of billed services that can be submitted to your insurance company for consideration of payment.

5. Is Brain SPECT Scan for diagnostic purposes only, or can it actually help me?

Diagnostic tests are meant to help a medical expert support or confirm a diagnosis; or to indicate that a diagnosis is less likely or not present. A Brain SPECT scan can be used to help determine parts of the brain that are working appropriately, underworking, or overworking. Brain work activity is based on the amount of tracer uptake in certain parts of the brain during rest and during stress or concentration. The information from the SPECT scan coupled with clinical history can help to diagnose or confirm specific brain disorders. These could include traumatic brain disorders (TBI), stroke, dementia, long covid, and various mental health disorders to include anxiety, depression, OCD, ADD/ADHD, and others. The additional data from Brain SPECT can be particularly helpful in situations where the diagnosis is not obvious and when typical treatments are not working.

6. Do I need a Brain SPECT Scan with my Ketamine Infusion?

At Lone Star Infusion Ketamine clinic, we take a multidisciplinary approach to your care. Some patients come to LSI with a team already in place that may include a psychiatrist, therapist, life coach, and others. Many patients request help from Lone Star Infusion because their condition has been difficult to diagnose and/or treatment resistant. In some cases, a Brain SPECT Scan may help to better focus our multidisciplinary approach and therapy.

7. Is having a SPECT Scan very involved? What if I am claustrophobic?

Brain SPECT Scans typically take about 20 minutes to complete a scan.  There is more preparation time, including IV placement and injection of the tracer. For the concentration scans, a concentration test is performed which the tracer is injected. There is then a waiting period to allow the tracer to taken up in the active parts of the brain before the Brain SPECT Scan is performed. The entire process may take 2-3 hours. See the brief video that outlines and illustrates the process.

Contact Lone Star Infusion to discuss you case, determine if SPECT Scan is right for you.

Important Notice Regarding Discontinuation of Ketamine Treatment Services

Lone Star Infusion will discontinue providing ketamine infusion and treatment services effective February 23, 2026. This decision was not made lightly, and we understand this news may be concerning to you.

What This Means for Your Care

After February 23, 2026 our clinic will no longer provide ketamine treatments. You will need to establish care with another provider to continue ketamine therapy, or work with your treating psychiatrist or pain management physician to explore alternative treatment options.

Your Immediate Next Steps

  1. Contact your prescribing psychiatrist, primary care physician, or pain management specialist to discuss your ongoing treatment plan and alternatives.
  2. If you wish to continue ketamine therapy, please review the enclosed list of physician-supervised ketamine clinics in the Houston area. We do not endorse any particular provider; this list is provided for your convenience only.
  3. Contact our office to schedule any final appointments before [closure date] and to discuss your transition of care.

Your Medical Records

Your treatment records will remain available through Lone Star Infusion. To request copies of your records or to authorize transfer to a new provider, please contact our office at 281.947.3268 or send a written request to 14740 Barryknoll Lane, Ste. 140, Houston, TX 77079. There is no charge for transferring records to your new treatment provider.

Continuation of Care During Transition

We stay committed to your care during this transition period. Please contact our office at 281.947.3268 if you have questions, need to schedule appointments before our closure date, or require assistance with your transition to a new provider.

We understand this transition may be difficult, and we appreciate the trust you have placed in us for your care. Our staff is available to assist you during this process.

Sincerely,
Chauncey Jones, M.D.
Lone Star Infusion