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Ketamine for Depression – Our Results

For treating depression with ketamine infusions: This study reviewing our results shows an overall response rate above 70% for patients who receive an initial series of treatments either once a week or twice a week.

PDF: The Effect of Ketamine Infusion Treatment Schedule on Depression Severity

 

YOUR SCHEDULE OF TREATMENTS:

This detailed look at our results shows a significant reduction in depression scores for patients. And it demonstrates that patients who receive an initial series of treatments on weekly or twice-a-week schedules see comparable results over the same number of treatments – meaning that you can see the same results faster if you space treatments closer together but can expect to see the same results eventually regardless.

We typically see patients for the treatment of depression either once a week or twice a week for an initial series of ketamine treatments. Work schedules, travel requirements, or other factors often compel the once-a-week schedule.

This analysis is consistent with our understanding of other research, and what we’d seen in the clinic. It’s excellent to have a thorough review of the data which concludes no difference between these two frequencies of visits. This is good information for those who are compelled to receive treatments once a week for an initial series.

 

YOUR RESPONSE TO TREATMENTS:

A response rate over 70% is great!

This response is consistent with many studies, except that our patients are widely dispersed in age, and concurrent medications, and diagnoses, and other characteristics. In other words, it appears that we are able to achieve an excellent response rate in the ‘naturalistic’ setting for our patients without the typically restrictive requirements of a research study.

We do not yet know what distinguishes someone who will respond and someone who will not respond to treatments. We suspect that one significant factor is likely whether a patient takes benzodiazepines or regularly consumes a moderate or greater amount of alcohol. Researchers on this subject have also hypothesized that there may be some genetic component to whether a patient responds to treatment or not.

 

TOWARDS THE BEST-POSSIBLE MEDICINE:

This study reviews our anonymized data from Lone Star Infusion shared with Dr. O’Brien, Dr. Mathew, Dr. Lijffift and Ms. Davis with Baylor College of Medicine and the Michael E. Debakey VA Medical Center with whom we collaborate. We strive to provide the best possible medicine including using – and contributing to – research. This collaboration and this study are a result of that effort to do the best we can, as well as contribute to the medical community for the benefit of patients.

 

THE STUDY:

PDF: The Effect of Ketamine Infusion Treatment Schedule on Depression Severity

An Important Disclaimer: The information in this and other blog posts represents our informed opinion or the opinion of others, and does not constitute medical advice and should not be relied upon to make decisions regarding medical care. To address the specific details of your medical conditions and treatments please speak with your doctors.

Important Notice Regarding Discontinuation of Ketamine Treatment Services

Lone Star Infusion will discontinue providing ketamine infusion and treatment services effective February 23, 2026. This decision was not made lightly, and we understand this news may be concerning to you.

What This Means for Your Care

After February 23, 2026 our clinic will no longer provide ketamine treatments. You will need to establish care with another provider to continue ketamine therapy, or work with your treating psychiatrist or pain management physician to explore alternative treatment options.

Your Immediate Next Steps

  1. Contact your prescribing psychiatrist, primary care physician, or pain management specialist to discuss your ongoing treatment plan and alternatives.
  2. If you wish to continue ketamine therapy, please review the enclosed list of physician-supervised ketamine clinics in the Houston area. We do not endorse any particular provider; this list is provided for your convenience only.
  3. Contact our office to schedule any final appointments before [closure date] and to discuss your transition of care.

Your Medical Records

Your treatment records will remain available through Lone Star Infusion. To request copies of your records or to authorize transfer to a new provider, please contact our office at 281.947.3268 or send a written request to 14740 Barryknoll Lane, Ste. 140, Houston, TX 77079. There is no charge for transferring records to your new treatment provider.

Continuation of Care During Transition

We stay committed to your care during this transition period. Please contact our office at 281.947.3268 if you have questions, need to schedule appointments before our closure date, or require assistance with your transition to a new provider.

We understand this transition may be difficult, and we appreciate the trust you have placed in us for your care. Our staff is available to assist you during this process.

Sincerely,
Chauncey Jones, M.D.
Lone Star Infusion