Research

Here is a selection of links and research articles on ketamine and lidocaine for depression, PTSD, pain, and other conditions. The articles here represent a portion of the information available, and are meant to supplement your own research and discussions with your referring physician.

Medical Literature

 

Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression

• Marije aan het Rot
• Katherine A. Collins
• James W. Murrough
• Andrew M. Perez
• David L. Reich
• Dennis S. Charney
• Sanjay J. Mathew

 

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

• Anita E. Autry
• Megumi Adachi
• Elena Nosyreva
• Elisa S. Na
• Maarten F. Los
• Peng-fei Cheng
• Ege T. Kavalali
• Lisa M. Monteggia

 

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

• Nancy Diazgranados
• Lobna Ibrahim
• Nancy E. Brutsche
• Andrew Newberg
• Phillip Kronstein
• Sami Khalife
• William A. Kammerer
• et al

 

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

• Ronald S. Duman
• George K. Aghajanian

 

Signaling Pathways Underlying the Rapid Antidepressant Actions of Ketamine

• Ronald S. Duman
• Nanxin Li
• Rong-Jian Liu
• Vanja Duric
• George K. Aghajanian

 

Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder: A Randomized Clinical Trial

• Adriana Feder
• Michael K. Parides
• James W. Murrough
• Andrew M. Perez
• Julia E. Morgan
• Shireen Saxena
• Katherine Kirkwood
• et al

 

Multi-Day Low Dose Ketamine Infusion for the Treatment of Complex Regional Pain Syndrome

• Michael E. Goldberg
• Richard Domsky
• Denise Scaringe
• Robert Hirsh
• Jessie Dotson
• Imran Sharaf
• Marc C. Torjman
• Robert J. Schwartzman

 

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

• Nanxin Li
• Rong-Jian Liu
• Jason M. Dwyer
• Xiao-Yuan Li
• George Aghajanian
• Ronald S. Duman
• et al

 

Maintenance Ketamine Treatment Produces Long-term Recovery from Depression

• Michael M. Messer
• Irina V. Haller

Primary Psychiatry

 

Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial

• James W. Murrough
• Dan V. Iosifescu
• Lee C. Chang
• Rayan K. Al Jurdi
• Charles E. Green
• Andrew M. Perez
• et al

 

Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression

• James W. Murrough
• Andrew M. Perez
• Sarah Pillemer
• Jessica Stern
• Michael K. Parides
• Marije aan het Rot
• et al

 

Efficacy and adverse effects of intravenous lignocaine therapy in fibromyalgia syndrome

• Raphael JH
• Southall JL
• Treharne GJ
• Kitas GD

 

Intravenous Therapies in the Management of Neuropathic Pain: A Review on the Use of Ketamine and Lidocaine in Chronic Pain Management

• Harsha Shanthanna

 

Differential Efficacy of Ketamine in the Acute versus Chronic Stages of Complex Regional Pain Syndrome in Mice

• Maral Tajerian
• David Leu
• Phillip Yang
• Ting Ting Huang
• Wade S. Kingery
• J. David Clark

 

A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression

• Carlos A. Zarate
• Jaskaran B. Singh
• Paul J. Carlson
• Nancy E. Brutsche
• Rezvan Ameli
• et al

 

The Impact of Childhood Maltreatment on Intravenous Ketamine Outcomes in Adult Patients with TreatmentResistant Depression

• Brittany O'Brien
• Marijn Lijffijt
• Allison Wells
• Alan C Swann
• Sanjay J Mathew

STUDIES

 

The Effect of Ketamine Infusion Treatment Schedule on Depression Severity

• Brittany O'Brien
• Allison Wells
• Marijin Lijffijt
• Michelle Davis
• Jesse Wells
• Alan C. Swann
• Sanjay J. Mathew

 

Does Childhood Trauma Impact Outcomes in Adults Receiving Ketamine for Depression?

• Brittany O'Brien
• Allison Wells
• Marijin Lijffijt
• Michelle Davis
• Jesse Wells
• Alan C. Swann
• Sanjay J. Mathew

 

The Impact of Childhood Maltreatment on Intravenous Ketamine Outcomes for Adult Patients with Treatment-Resistant Depression

• Brittany O'Brien
• Marijin Lijffijt
• Allison Wells
• Alan C. Swann
• Sanjay J. Mathew