Here is a selection of links and research articles on ketamine and lidocaine for depression, PTSD, pain, and other conditions. The articles here represent a portion of the information available, and are meant to supplement your own research and discussions with your referring physician.



1) The Effect of Ketamine Infusion Treatment Schedule on Depression Severity

2) Does Childhood Trauma Impact Outcomes in Adults Receiving Ketamine for Depression?

3) The Impact of Childhood Maltreatment on Intravenous Ketamine Outcomes for Adult Patients with Treatment-Resistant Depression


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Medical Literature:

aan het Rot et al.

Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression

Autry et al.

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

Diazgranados et al.

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

Duman and Aghajanian

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

Duman et al.

Signaling Pathways Underlying the Rapid Antidepressant Actions of Ketamine

Feder et al.

Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder: A Randomized Clinical Trial


Multi-day low dose ketamine infusion for the treatment of complex regional pain syndrome.

Li et al.

Glutamate NMDA receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure

Messer and Haller

Maintenance Ketamine Treatment Produces Long-term Recovery from Depression

Murrough et al.

Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial

Murrough et al.

Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression

Raphael et al.

Efficacy and adverse effects of intravenous lignocaine therapy in fibromyalgia syndrome


Intravenous Therapies in the Management of Neuropathic Pain: A Review on the Use of Ketamine and Lidocaine in Chronic Pain Management

Tajerian et al.

Differential Efficacy of Ketamine in the Acute versus Chronic Stages of Complex Regional Pain Syndrome in Mice (Full text requires login).

Zarate et al.

A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression

The Impact of Childhood Maltreatment on Intravenous Ketamine Outcomes in Adult Patients with Treatment-Resistant Depression

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